Formulation evaluation of terbutaline sulfate sublingual tablet by using natural superdisintegrants

Abstract

Terbutaline sulfate is a selective B2 bronchodilator which is used in the treatment of asthma. Conventional

Terbutaline tablets available in the market are not suitable where quick onset of action is required. Terbutaline

sulfate sublingual tablets were prepared by using mannitol, Aspartame, aerosil, magnesium steartate, talc and

natural superdisintegrants like karaya gum, locust bean gum, gellan gum by direct compression method.F11

formulation of locust bean gum was selected as best formulation. It was shown less disintegration time of 17

seconds. It was observed that less disintegration time was observed when locust bean gum was used as natural

superdisintegrant, may be due to swelling at faster rate upon contact with water and elimination of lump

formation after disintegration when compared with gum karaya and gellan gum. F11 formulation was found to

be the best as this formulation shown less disintegration time and possessing good tabletting properties. The

bioavailability of terbutaline sulfate is 14.8%. Bioavailability also can be increased using natural

superdisintegrants. Sublingual absorption avoids first pass metabolism.