Design of Nanogel Formulation of Naproxen for Enhanced Anti-Inflammatory Effect: A Comprehensive Review

Abstract

As a commonly prescribed nanogel, naproxen is an NSAID used in the treatment of many acute and chronic inflammatory conditions. But because of poor aqueous solubility, side effects related to the gastrointestinal tract after oral use, and poor skin permeation with regular topical treatments, its clinical use is limited. Recent literature in PubMed reports nanogel-based drug delivery systems as a promising means to overcome these obstacles by improving drug solubility and skin penetration as well as providing controlled and sustained drug release at the target site for inflammation. This review examines the design principles, selections of polymers, formulation methodologies, characterization methodologies, and naproxen-loaded nanogel systems anti-inflammatory activities for nanogels. Advanced safety features and clinical application of naproxen nanogel formulations, as well as naproxen’s release from the nanogel, will also be discussed.