Formulation And Evaluation Of Doxycycline Hyclate Insitu Gel For The Treatment Of Paronychia

Abstract

The study focuses on the formulation and evaluation of doxycycline-loaded in-situ gel for the localized treatment of paronychia. The in-situ gel system was designed to provide sustained drug release and improve therapeutic efficacy while minimizing systemic side effects. Various formulations were prepared and optimized for gelling capacity, viscosity, drug encapsulation efficiency, and in-vitro drug release. The optimized formulations, particularly F3 and F4, demonstrated high drug encapsulation efficiency (up to 97.89%), excellent gelling capacity, and prolonged drug release over 24 hours. Stability studies confirmed the physical and chemical robustness of the formulations, maintaining consistent drug content and gelling properties under standard and accelerated conditions. These results highlight the potential of doxycycline-loaded in-situ gel as an effective and convenient treatment for paronychia, warranting further in-vivo and clinical investigations.