Formulation, optimization, and evaluation of procyclidine hydrochloride loaded solid lipid nanoparticles using design of experiment

Abstract

This study presents the formulation, optimization, and evaluation of Procyclidine Hydrochloride-loaded Solid Lipid Nanoparticles (SLNs) to enhance the drug's therapeutic efficacy. The SLNs were optimized using a Box-Behnken Design, focusing on parameters such as oleic acid, Tween 80, and propylene glycol. The optimized formulation exhibited a particle size of 259 nm, a polydispersity index (PDI) of 0.3169, and a zeta potential of -32.01 mV, indicating high stability. In-vitro drug release studies demonstrated sustained release over 24 hours, achieving 94.15% cumulative release. Stability studies confirmed the formulation's robustness under various storage conditions. These results suggest that SLNs are an effective drug delivery system for enhancing the bioavailability and controlled release of Procyclidine Hydrochloride.