Spectrophotometric Determination of Levetiracetam Using 2, 4-DNP and MBTH in Pharmaceutical Dosage Form

https://doi.org/10.61096/ijpir.v8.iss2.2018.95-103

Authors

  • R.S. Chandan Department of Pharmaceutical Analysis, JSS Academy of Higher Education & Research, JSS College of Pharmacy, Mysore 570 015, (KA), India
  • M. Indupriya Department of Pharmaceutical Analysis, JSS Academy of Higher Education & Research, JSS College of Pharmacy, Mysore 570 015, (KA), India
  • P.Lavanya Department of Pharmaceutical Analysis, JSS Academy of Higher Education & Research, JSS College of Pharmacy, Mysore 570 015, (KA), India.

Keywords:

Spectrophotometric, Oxidative coupling, 2, 4-Dinitrophenyl hydrazine (2, 4-DNP), 3-Methyl-2- Benzthiazolinone hydrochloride (MBTH), Levetiracetam. Reliability, Statistically

Abstract

Purpose

This study was aimed to evaluate the method of Spectrophotometric Determination of Levetiracetam Using 2, 4-DNP

and MBTH in Pharmaceutical Dosage Form.

Findings

Levetiracetam at its λmax 455 nm shows linearity in the concentration range of 30-130 µg mL-1. Second method is

based on reaction of oxidative coupling of levetiracetam with 3-Methyl-2-Benzthiazolinone hydrochloride (MBTH)

to form green colored product. Levetiracetam at its λmax 634 nm shows linearity in the concentration range of 20-

100 µg mL-1. The relative standard deviations for first method is 0.422% and for second method is 0.325% were

obtained.

Conclusion

The reliability and performance of the proposed methods was validated statistically the percentage recovery ranged

from 99.88 and 100.2 respectively. The results of analysis for the two methods have been validated statistically and

by recovery studies.

 

Dimensions

Published

2018-06-13

Issue

Vol. 8 No. 2 (2018): 2018 Volume -8 - Issue 2

Section

Articles
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