Formulation And In-Vitro Evaluation Of Extended Release Tablets Of Metoclopromide Hcl Using Natural And Synthetic Polymers

Abstract

The aim of the present study was to develop Metoclopramide HCl Controlled release tablets to maintain constant therapeutic levels of the drug for over 12 hrs. Xanthan gum, Guar gum, Carbopol 934 were used as polymers. All the formulations were passed various physicochemical evaluation parameters such as bulk density, tapped density, carrs index, hausners ratio, angle of repose, weight variation, hardness, thickness, friability and drug content. From the dissolution studies it was evident that the formulation F6 showed better and desired drug release pattern i.e., 98.10 % in 12 hours. It contains the Carbopol 934 as polymer. It followed zero order release kinetics mechanism.