SYNTHESIS, SPECTRAL CHARACTERIZATION, PHARMACOLOGICAL EVALUATION OF CERTAIN 2-SUBSTITUTED BENZIMIDAZOLYL CHALCONES FOR IN-VIVO ANALGESIC, ANTI-INFLAMMATORY AND CENTRAL NERVOUS SYSTEM ACTIVITIES.

Abstract

A series of 2-substituted benzimidazolyl chalcones were synthesized by condensation reaction of 1-(1H- benzoimidazol-2-yl)ethanone with various substituted aromatic aldehydes in presence of mild alkali. The 1- (1H-benzoimidazol-2-yl)ethanone was synthesized by oxidation of 1-(1H-benzoimidazol-2-yl)ethanol, which was synthesized by cyclisation reaction of orthophenylenediamine with 2-hydroxypropanoicacid. The yields of the synthesized benzimidazoles were ranged 52-81%. The structures of the synthesized benzimidazolyl chalcones were characterized and confirmed by FTIR,1H-NMR,13C-NMR and mass spectral data analysis. The synthesized benzimidazolyl chalcones were screened for their In-vivo analgesic, anti-inflammatory and central nervous system locomotor activities. All the synthesized benzimidazolyl chalcones showed moderate to

appreciable significant analgesic activity and also some the compounds exhibited significant good anti-

Introindfluacmtimoantory properties (except 6e & 6h). Among this tested benzimidazolyl chalcones only 6d, 6f, 6g and 6h

has depicted considerable central nervous system depressant activity.