Synthesis, Characterization and Antibacterial Activity Using Mannich Base, N-[(1-Morpholinobenzyl)] Benzamide: A Structure and Reactivity Study

Abstract

The substituted Mannich base is prepared by condensation of substituted benzaldehyde with benzamide and secondary amine. Like morpholine. The synthesized morpholinobenzyl benzamide undergoes NMR and IR spectral studies. The anti microbial activity of various substituted N-[(1-Morpholinobenzyl)] benzamide compounds studied against various organisms such as staphylococcus aureus, bacillus subtilis, Escherichia coli and pseudomonas aeruginosa by well diffusion method using DMSO as solvent. The values of zone of inhibition were found out at 370c for a period of 24 h. It has been found that all the inhibitory action gets enhanced with the introduction of electron withdrawing groups in the phenyl ring.