EVALUATION OF ANTIULCER ACTIVITY IN THE METHANOL EXTRACT OF ACANTHUS ILICIFOLIUS LEAVES IN EXPERIMENTAL RATS

Authors

  • Nizamuddin Basha S S.K.University, Anantapur, India - 515 055.
  • Chitta Suresh S.K.University, Anantapur, India - 515 055.
  • Danamma B S.K.University, Anantapur, India - 515 055.
  • Mohd Dada Vels University, Chennai, Tamilnadu, India-600 117.
  • Abdul Maajid Islamia college, Vaniyambadi, Tamilnadu, India-635 751.

Keywords:

Acanthus ilicifolius, Methanol extract, Pylorus ligation, Ulcer index.

Abstract

The anti-ulcer activity of Methanolic extracts of Acanthus ilicifolius Leaves (MEAI) was investigated in pylorus ligation and ethanol induced ulcer models in wistar albino rats. In both models, the common parameter determined was the ulcer index. MEAI at doses of 100, 200mg per kg body weight produced significant inhibition of the gastric lesions induced by pylorus ligation and ethanol induced gastric ulcers. The extract showed the significant reduction in the gastric volume, free acidity and ulcer index as compare to control. This present study indicates that Acanthus ilicifolius have potential anti ulcer activity in the both models. These results may further suggest that the Leaf Methanolic extracts were found to possess anti ulcerogenic as well as ulcer healing properties, which might be due to anti secretary activity.

 

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Published

2011-03-10

Issue

Vol. 1 No. 1 (2011): 2011 Volume -1 - Issue 1

Section

Articles
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