FORMULATION AND EVALUATION OF CAPTOPRIL GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM

Authors

  • Vijayasankar G R Vishwa Bharathi college of Pharmaceutical Sciences, Guntur, Andhrapradesh, India-522009
  • Naveen Kumar Jakki S Santhiram college of Pharmacy, Nandyal, Andhrapradesh, India-518112.
  • Suresh AG Santhiram college of Pharmacy, Nandyal, Andhrapradesh, India-518112.
  • Packialakshmi M Schaavan college of Pharmacy, Nellore, Andhrapradesh, India- 524003.

Keywords:

Captopril, Hydroxypropyl methyl cellulose, Gastroretentive oral controlled.

Abstract

The present study is the most feasible approach to control the gastric residence time using gastroretentive dosage forms with required efficacy, safety and stability of the drug. Three different grades of Hydroxypropyl Methyl cellulose, Lactose, Sodium bicarbonate and Magnesium stearate were used as a variant with Captopril as active pharmaceutical ingredient. The tablets were prepared by direct compression method. Differential Scanning Calorimetry (DSC) studies showed that no polymorphic changes occurred during manufacturing of tablets. Observations of all formulations for

Dimensions

Published

2011-01-05

Issue

Vol. 1 No. 1 (2011): 2011 Volume -1 - Issue 1

Section

Articles
Copyright & Licensing
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