FORMULATION AND EVALUATION OF CAPTOPRIL GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM

Abstract

The present study is the most feasible approach to control the gastric residence time using gastroretentive dosage forms

with required efficacy, safety and stability of the drug. Three different grades of Hydroxypropyl Methyl cellulose,

Lactose, Sodium bicarbonate and Magnesium stearate were used as a variant with Captopril as active pharmaceutical

ingredient. The tablets were prepared by direct compression method. Differential Scanning Calorimetry (DSC) studies

showed that no polymorphic changes occurred during manufacturing of tablets. Observations of all formulations for

physical characterization had shown that, all of them comply with the specifications of official pharmacopoeias. Results of

in vitro release profile indicated that formulation (F5) was the most promising formulation as the extent of drug release

from this formulation was high as compared to other formulations. Results of in-vitro swelling study indicate that the

formulation F5 was having considerable swelling index. From the in vitro buoyancy studies, it was found that almost all the

batches containing effervescent agent showed immediate floatation followed by floatation period of more than 8h. It was

concluded that the tablets of batch F5 had considerable swelling behaviors and in vitro drug release. It was observed that

tablets of batch F5 followed the Higuchi modal release profiles. From the results obtained, it was concluded that the

formulation F5 is the best formulations as the extent of drug release was found to be around 96.22 % at the desired time

8hour. This batch also showed immediate floatation and floatation duration of more than 8hour.