DEVELOPMENT AND EVALUATION OF CINNAMON AND ALOE-VERA CONTAINING HERBAL ANTI-ACNE GEL

Abstract

In the present study an attempt was made to formulate gel containing cinnamon oil. The result showed that the optimal formula of anti-acne gel with cinnamon oil and aloevera gel contained cinnamon oil 0.5%, aloevera gel 10%, BHT 1%, Ascorbic acid 0.1%, Carbopol-971 1.75%, Coco diethanol amine q.s. to neutral pH, and water

q.s to 100 ml. Anti acne gel with cinnamon oil was clear, transparent, thick, smooth gel. The gel pH was 6.53 and its viscosity was 3600 cP. It was non irritant to skin. In vitro antibacterial activity was performed against Propionibacterium acnes MTCC 3297, a causative organism for Acne vulgar for the developed formulations using agar well diffusion method. The measured zones of inhibitions of the formulations were compared with standard antibiotic Clindamycin (Erytop), standard marketed topical preparation for acne. Results of the investigation showed that formulation has greater antibacterial activity (zones of inhibition >18 mm) which is comparable to that of standard marketed topical preparation. The gel was stable at room temperature.