DEVELOPMENT AND VALIDATION OF SPECTROSCOPIC METHOD FOR THE ESTIMATION OF NAFTOPIDIL IN BULK AND DOSAGE FORM

Authors

  • M.Sunil kumar Srikakathiya Institute of Pharmaceutical Sciences, Hanamkkonda, Warangal, A.P. India.
  • K.Priyanka Srikakathiya Institute of Pharmaceutical Sciences, Hanamkkonda, Warangal, A.P. India.
  • M.Manasa Srikakathiya Institute of Pharmaceutical Sciences, Hanamkkonda, Warangal, A.P. India.
  • M.Swapna Talla Padmavathi college of Pharmacy, Orus, Warangal, A.P. India.
  • V.Kirankumar Unity college of pharmacy, Raigir, Bhongir, Nalgonda, A.P. India

Keywords:

Naftopidil, UV-spectroscopy, Validation, Recovery

Abstract

A simple, rapid and sensitive method has been developed for the quantitative estimation of n in bulk and tablet. The wavelength 285 nm was selected for the estimation of drug using distilled water: acetonitrile (50:50) as a solvent. The drug obeyed Beer-lambert’s law over the concentration range 5-25mg/ml. The accuracy of the method was assessed by recovery studies and was found between 99.73-100.17%. The method was statistically validated for the linearity, precision, accuracy, repeatability, LOD, LOQ and ruggedness. The method was successfully applied for routine analysis of this drug in bulk and formulations.

Dimensions

Published

2012-11-01

Issue

Vol. 2 No. 4 (2012): 2012 Volume -2 - Issue 4

Section

Articles
Copyright & Licensing
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