STUDIES ON ANTIVIRAL ACTIVITIES AND CYTOTOXICITY OF ISATINE- SULPHONAMIDES AGAINST ORTHOPOX VIRUSES

Authors

  • Periyasamy Selvam Raghavendra Institute of Pharmaceutical Education and Research, Anantapur 515 721, AP

Keywords:

Isatin, Sulphadimidine, Antiviral activity, Vaccinia virus, Cow pox virus

Abstract

Series of Isatine-Sulphonamide derivatives were synthesized and tested for antiviral activity against orthopox virus in human foreskin fibroblast (HFF) cells. Cytotoxicity was investigated in uninfected HFF cells. Compound SPIII-5Br-AC (EC50 12 uM and CC50 >300 uM) exhibits equipotent activity with that of standard Cidofovir (CDV) (EC50 16.2 uM and CC50 >317 uM) against cowpox virus in CPE reduction assays.

Dimensions

Published

2012-10-18

Issue

Vol. 2 No. 4 (2012): 2012 Volume -2 - Issue 4

Section

Articles
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