FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING BIOADHESIVE TABLETS OF TINIDAZOLE

Abstract

Tinidazole is an Anti-amoebic, Anti-protozoal, Anti-bacterial, Antibiotic type of drug. That is practically active against amoebiasis, protozoa, trichomoniasis, giardiasis and bacteria.. The purpose of this investigation is to improve bioavailability by preparing a gastroretentive drug delivery system. Floating tablets of Tinidazole were prepared by employing two different grades of HPMC K4M and HPMC E15M in different concentrations by effervescent granulation technique. These grades of HPMC K4M and HPMC E15M were evaluated for their gel forming properties. Sodium bicarbonate was incorporated as a gas-generating agent. The tablets were evaluated for uniformity of weight, hardness, friability, drug content, in vitro buoyancy and dissolution studies. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. Among tablet formulations, formulation F3 gives best disintegration and dissolution profile compared with other formulations.