PREPARATION OF VILOXAZINE SUSTAINED RELEASE DRUG DELIVERY SYSTEM BY USING HYDROPHILIC BIOPOLYMER HYDROXY PROPYL METHYL CELLULOSE

Authors

  • HariHaran D Annai Veilankanni’s College of Pharmacy, Saidapet, Chennai, Tamilnadu, India - 600015.
  • Senthilkumar M Annai Veilankanni’s College of Pharmacy, Saidapet, Chennai, Tamilnadu, India - 600015.
  • Suresh babu N Annai Veilankanni’s College of Pharmacy, Saidapet, Chennai, Tamilnadu, India - 600015.
  • Mohan M Annai Veilankanni’s College of Pharmacy, Saidapet, Chennai, Tamilnadu, India - 600015.
  • Valarmathi S Annai Veilankanni’s College of Pharmacy, Saidapet, Chennai, Tamilnadu, India - 600015.

Keywords:

Hydrophilic, Hydroxy propyl methyl cellulose, Viloxazine, Sustained release tablets, UV Analysis.

Abstract

The present study behind this work is to find to prepare sustained release tablets of Viloxazine by compression method. First of all to formulate Viloxazine sustained release tablets using the hydroxy propyl methyl cellulose under various ratio’s like 1:0.25, 1:0.50, 1:0.75,1:1.00,1:1.25 .Five batches were made in various concentrations of hydroxy propyl methyl cellulose is used by keeping the drug as constant. Then evaluation of Viloxazine sustained release tablets was carried out for characteristics like drug content in tablet, UV analysis. In vitro release starts from 1hr and up to 24hrs. It shows the percentage of gradual drug release as 17.6%, 27.0%, 34.67%, 44.14%, 50.23%, 56.39%, 60.42%, 65.88%, 71.15%, 76.42%, 81.29%, 84.22% & 98.14% against the

label claim as 40mg.

Dimensions

Published

2012-10-02

Issue

Vol. 2 No. 4 (2012): 2012 Volume -2 - Issue 4

Section

Articles
Copyright & Licensing
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