COMPARITIVE IN-VITRO EVALUATION OF DIFFERENT BRANDS OF CLONAZEPAM TABLETS

Authors

  • Lalithakumari Ch T Nalanda Institute of Pharmaceutical sciences, Kantepudi, Sattenapalli, Andhra Pradesh, India – 522 438.
  • Desireddy R B Nalanda Institute of Pharmaceutical sciences, Kantepudi, Sattenapalli, Andhra Pradesh, India – 522 438.
  • Sindhuri S L Nalanda Institute of Pharmaceutical sciences, Kantepudi, Sattenapalli, Andhra Pradesh, India – 522 438.
  • Bandhavi P Nalanda Institute of Pharmaceutical sciences, Kantepudi, Sattenapalli, Andhra Pradesh, India – 522 438.
  • Anuradha Ch Nalanda Institute of Pharmaceutical sciences, Kantepudi, Sattenapalli, Andhra Pradesh, India – 522 438.

Keywords:

Clonazepam , Disintegration, Dissolution, Crushing strength, Friability.

Abstract

This study was concerned to assess the quality of different brands of Clonazepam tablets by evaluating & comparing the physico-chemical properties such as uniformity of weight, crushing strength, friability, disintegration, in-vitro dissolution of the drug along with drug content(assay). All the evaluated brands of Clonazepam tablets compiled with USP specifications for uniformity of weight, friability, crushing strength & disintegration. The amount of drug obtained & % purity was found to be less when compared to that of label claim. Among the five brands, 0.25mg & 0.5mg of Clonazepam tablets i.e., A1 & B4 was found to have more amount of drug. In the assay of Clonazepam tablets the UV method used was followedwhich is an simple, reproducible & economical method especially in the absence of high technology equipments that are not easily available in small scale laboratories.

Dimensions

Published

2012-09-17

Issue

Vol. 2 No. 3 (2012): 2012 Volume -2 - Issue 3

Section

Articles
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