Design, development and evaluation of nifedipine polymeric microspheres

Authors

  • Milan Nandi Bengal College of Pharmaceutical Sciences and Research, Durgapur, West Bengal, India
  • Mithun Bhowmik Bengal College of Pharmaceutical Sciences and Research, Durgapur, West Bengal, India
  • Soumik Laha Bengal College of Pharmaceutical Sciences and Research, Durgapur, West Bengal, India
  • Pratibha Bhowmick Bengal College of Pharmaceutical Sciences and Research, Durgapur, West Bengal, India

Keywords:

Nifedipine, Eudragit, Carbopol 934p, HPMC, Solvent evaporation method and microspheres

Abstract

The aim of the study was to prepare Nifedipine microspheres using Solvent evaporation method using different polymer ratio. FT-IR
studies revealed that there was no chemical interaction between the drug and polymer.The average particle size of the optimized
formulation was found to be 166μm. The in-vitro release behavior from all the Nifedipine microspheres was found to be peppas drug
release kinetics and produced a sustainedrelease over a period of 12 hours with better entrapment efficiency

Dimensions

Published

2023-05-13

Issue

Vol. 13 No. 2 (2023): 2023 Volume -13 - Issue 2

Section

Articles
Copyright & Licensing
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