Formulation development and evaluation of dorzolamide hydrochloride nanoparticles

Abstract

The objective of this present work was to develop Nanoparticle of Dorzolamide hydrochloride. The proposed Dorzolamide
hydrochloride polymer loaded with nanoparticles was prepared by emulsification sonication method. Nanoparticles represent a
promising drug delivery system of sustained and targeted drug release. They are specially designed to release the drug in the vicinity of target tissue. The aim of this study was to prepare and evaluate polymer loaded nanoparticles containing Dorzolamide hydrochloride in different drug to polymer ratio. SEM indicated that nanoparticles have a discrete spherical structure. FT-IR studies indicated that there was no chemical interaction between drug and polymer and stability of drug. The in vitro release behavior from all the drug loaded batches was found to be Peppas release and provided sustained release over a period of 48 h. The developed formulation overcome and alleviates the drawbacks and limitations of Dorzolamide hydrochloride sustained release formulations and could possibility be advantageous in terms of increased bioavailability of Dorzolamide hydrochloride.