EVALUATION OF ANTI-CANCER ACTIVITY OF ETHANOL EXTRACT OF ERYTHRINA VARIEGATA LINN.

Abstract

Ethanol Extract of Erythrina variegata was investigated for anticancer and invitro cytotoxic activities against transplantable tumors and human cell line. Invitro cycotoxicity studies were carried out using Hela and NIH3T3 cells by MTT assay and in vivo antitumor activity with Dalton’s Ascites lymphoma (DLA) tumor bearing mice. Activity was measured by monitoring the Cancer Cell number, packed cell volume, increase in life span and haemetological parameters were evaluated and compared with the respective controls. The extract exhibited strong in vitro cytotoxicity against Hela cell line found to be safe with normal cell.   EEEV with the doses 200 and 400 mg/kg. Significantly increase the life span and decrease in the cancer cell number and tumor weight (P <0.01), exerted a protective effect on the hemopoietic system. Results showed significant antitumor and cytotoxics effects of EEEV against DLA and human Cancer Cell line which support the ethno medicinal use of EEEV in cancer therapy.