ANTI-INFLAMMATORY EFFECT OF ETHYL ACETATE ACTIVE FRACTION OF BUTEA MONOSPERMA LEAVES

Authors

  • Raja Sreekanth M Dept of Agricultural Sciences, Loyola Academy, Old Alwal, Secunderabad, A.P, India - 500 010.
  • S Emmanuel S J Dept of Agricultural Sciences, Loyola Academy, Old Alwal, Secunderabad, A.P, India - 500 010.
  • Satish Adapa Dept of Agricultural Sciences, Loyola Academy, Old Alwal, Secunderabad, A.P, India - 500 010.

Keywords:

Anti-inflammatory, Butea monosperma; ethyl acetate active fractions, Complete Freund’s adjuvant.

Abstract

The present study was undertaken to assess the anti-inflammatory potential of the ethyl acetate active fractions of Butea monosperma leaves against Complete Freund’s Adjuvant (CFA) induced inflammation in wistar rats. Three different ethyl acetate active fractions of Butea monosperma leave (50, 100 & 250 mg/kg) showed a significant dose-dependent protective effect against CFA-induced inflammation. At the dose of 250 mg/kg, the percentage inhibition of inflammation was 30.45, 35.54, 39.88 and 44.1 on day 4th, 8th, 14th and 21st day respectively and oral administration of E.A active fraction of Butea monosperma leaves for 21 days significantly increased(P<0.05) the body weight in all treatment groups. These observations suggest possible therapeutic potential of the ethyl acetate active fractions of Butea monosperma leaves in inflammatory disorders like rheumatoid arthritis and other inflammatory diseases.

Dimensions

Published

2012-03-02

Issue

Vol. 2 No. 1 (2012): 2012 Volume -2 - Issue 1

Section

Articles
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