SYNTHESIS, CHARACTERIZATION AND ANALGESIC ACTIVITY OF 1,3,4-OXADIAZOLE DERIVATIVES

Abstract

Oxadiazole derivatives have played a vital part in the development of heterocyclic compounds. In this present work, a series of 5-(2-aminophenyl)-1,3,4-oxadiazole-2(3H)-thione derivatives (1a-f) have been synthesized by mannich reaction. The reaction progress of the synthesized compounds was checked by TLC. The structures of the newly synthesized compounds were confirmed by IR and 1H NMR spectral data. The analgesic activity of 1,3,4-oxadiazoles (1a-f) was assessed by hot plate and tail flick methods. Among the newly synthesized 1,3,4- oxadiazoles, compounds 1a,1b,1c,1d showed highly significant (p<0.001) analgesic activity in experimented animal models where, Pentazocine (5mg/ml, i.p.) was used as reference standard.