Formulation and evaluation of orally disintegrating tablets of ibuprofen with improved oral palatability
Keywords:
Pre-formulation parameters, Taste masking of tablets, Ibuprofen, Hydrophobic polymers, Oral dispersion.Abstract
The aim of this study was to formulate and evaluate the oral tablet formulations of Ibuprofen fast oral
disintegration and increasing the oral palatability by masking the bitter taste of the drug component. As the drug
imparts a bitter taste it is optimised in aspect of sweeteners and flavours also obtained by coating a different
polymer. The plan of work comprises of characterisation of API with pre formulation studies such as Angle of
Repose, Bulk Density, Tapped Density, Compressibility Index, Hausner’s Ratio, Particle Size Distribution, Drug
excipient comparability study, Solubility study. This is followed by taste masking achieved by addition of
sweeteners and flavours and coating with hydrophobic additives. The drug component then processed with the
developmental parameters such as Direct compression, Dry granulation and Wet granulation. This part of the
formulation is further scaled to identification and optimization of the disintegrants in the formulation. Once the
stability parameters of the formulation are accessed, it is then proceeded with analytical process conducted in
order to select and evaluate the best formulation among them.
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