Formulation and evaluation of orally disintegrating tablets of ibuprofen with improved oral palatability

Authors

  • Mohamed Rizwan Kareem Department of Pharmaceutics, JKKMMRF Annai JKK Sampoorani Ammal College of Pharmacy, Komarapalayam 638183
  • Chandra S; Kavibharathi S Department of Pharmaceutics, JKKMMRF Annai JKK Sampoorani Ammal College of Pharmacy, Komarapalayam 638183
  • Suresh R Department of Pharmaceutics, JKKMMRF Annai JKK Sampoorani Ammal College of Pharmacy, Komarapalayam 638183
  • Sangeetha Department of Pharmaceutics, JKKMMRF Annai JKK Sampoorani Ammal College of Pharmacy, Komarapalayam 638183
  • Sangeetha Department of Pharmaceutics, JKKMMRF Annai JKK Sampoorani Ammal College of Pharmacy, Komarapalayam 638183
  • Dhivya Bharathi P Department of Pharmaceutics, JKKMMRF Annai JKK Sampoorani Ammal College of Pharmacy, Komarapalayam 638183

Keywords:

Pre-formulation parameters, Taste masking of tablets, Ibuprofen, Hydrophobic polymers, Oral dispersion.

Abstract

The aim of this study was to formulate and evaluate the oral tablet formulations of Ibuprofen fast oral

disintegration and increasing the oral palatability by masking the bitter taste of the drug component. As the drug

imparts a bitter taste it is optimised in aspect of sweeteners and flavours also obtained by coating a different

polymer. The plan of work comprises of characterisation of API with pre formulation studies such as Angle of

Repose, Bulk Density, Tapped Density, Compressibility Index, Hausner’s Ratio, Particle Size Distribution, Drug

excipient comparability study, Solubility study. This is followed by taste masking achieved by addition of

sweeteners and flavours and coating with hydrophobic additives. The drug component then processed with the

developmental parameters such as Direct compression, Dry granulation and Wet granulation. This part of the

formulation is further scaled to identification and optimization of the disintegrants in the formulation. Once the

stability parameters of the formulation are accessed, it is then proceeded with analytical process conducted in

order to select and evaluate the best formulation among them.

Dimensions

Published

2021-09-13