Design and In-Vitro evaluation of immediate release tablets of a dibenzothiazepine derivative quetiapine fumerate: an anti-psychotic agent

Abstract

In the present intended research work, QUETIQPINE FUMERATE a dibenzothiazepine derivative was taken for

formulating immediate release tablets, used in the treatment of schizophrenia and major depressive disorders. To

prepare IR tablets microcrystalline cellulose and carboxy methyl cellulose was selected as major ingredients. Total

ten trials were afforded to get optimization IR tablets. Pre-compression and post compression in-vitro evaluation

parameters were found to be in average rage as bulk density- 0.23- 0.46, tap density 0.25-0.66, angle of repose

31.23-41.28 and compressibility index 27.58-38.23 and in case of post compression the values are hardness 3.4-5.7

kg/cm2, thickness 0.4-6.6 mm, diameter 0.9-1.0, weight variation of 340mg variation was in the range of 334-

345mg. and friability was found to be 0.26-0.75. Drug release of optimized trial T-10 after one month accelerated

stability studies was forum to be 100 percent within 60 minutes. An attempt was made for determination of release

rate kinetics and the prepared in-house IR tablets were showing the following order of release. KORESMEYER

PEPPAS PLOT with R2 value of 0.987>, HIGUCHIS PLOT with R2 0.976 = ZERO ORDER R2 0.976 >, FIRST

ORDER R2 0.855. The release of drug form QUETIAPINE FUMERATE immediate release tablets was found to be

following KORESMEYER PEPPAS plot of kinetics release.