Formulation, and evaluation of Fast Dissolving Oral Films of  Diphenhydramine Hydrochloride

J.Naga Sowjanya; Manichandrika; Shilukuri Akhila; Varigonda Bhavya Sri; A.Manju Bhargavi; Tokala Navya; Sangam Niharika

Authors

J.Naga Sowjanya
editorijpir@gmail.com
Bojjam Narasimhulu Pharmacy College for Women, Vinaynagar, Saidabad. Hyderabad-500059
Manichandrika Bojjam Narasimhulu Pharmacy College for Women, Vinaynagar, Saidabad. Hyderabad-500059
Shilukuri Akhila Bojjam Narasimhulu Pharmacy College for Women, Vinaynagar, Saidabad. Hyderabad-500059
Varigonda Bhavya Sri Bojjam Narasimhulu Pharmacy College for Women, Vinaynagar, Saidabad. Hyderabad-500059
A.Manju Bhargavi Bojjam Narasimhulu Pharmacy College for Women, Vinaynagar, Saidabad. Hyderabad-500059
Tokala Navya Bojjam Narasimhulu Pharmacy College for Women, Vinaynagar, Saidabad. Hyderabad-500059
Sangam Niharika Bojjam Narasimhulu Pharmacy College for Women, Vinaynagar, Saidabad. Hyderabad-500059

Keywords:

Diphenhydramine Hydrochloride, HPMC, Ethyl cellulose, FTIR studies, solvent casting technique, In-vitro drug release studies

Abstract

The objective of present study was to develop matrix type oral disintegrating film therapeutic systems of Diphenhydramine Hydrochloride using various polymers such as HPMC, Ethyl cellulose polymers as matrix formers by Solvent casting method. Results revealed that prepared films showed good physical characteristics, no drug-polymer interaction and no skin irritation was observed. The in vitro release study revealed that F5 formulation showed maximum release in 240 sec. For F5 Formulation In-vitro disintegration time was found to be 30sec, Thickness was 0.25mm, Folding endurance 79 and Swelling Index was 15.25. The F5 formulation
was found to be stable as there was no drastic change in the Physico-chemical properties of the films, which was also confirmed by FTIR. Thus, conclusion can be made that stable oral disintegrating film of Diphenhydramine Hydrochloride has been developed. F5 formulation showed highest cumulative percentage drug release of 98.6% obtained during In vitro drug release studies after 240 sec. Based upon the in vitro dissolution data the F5 formulation was concluded as optimized formulation.

Dimensions