Formulation, Development and In vitro Evaluation of Gatiflaxacin In-Situ G
Keywords:
Gemifloxacin, polymers, Gel strength, Bio availability, In vitro-drug releaseAbstract
Gatiflaxacin is a fluorinated 4-quinolone antibiotic which is used in the treatment of ophthalmic ailments like infections, inflammations, conjunctivitis, blepharitis, iritis, corneal ulcer etc. Commercially, Gatiflaxacin eye drop solution is available and it is quite easy for the administration. However, the product has drawback of poor bioavailability due to several factors such as tear production, nonproductive absorption, transient residence time, and impermeability of corneal epithelium. In order to improve the bioavailability, residence time and longer duration of action, an attempt was made to formulate in-situ ophthalmic gel of Gatiflaxacin. In present study Carbopol 934 and HPMC, HPMC 15K were used as polymers. Carbopol 934 was used as a pH sensitive polymer and HPMC, HPMC 15K was used as mucoadhesive polymer. All prepared formulations were evaluated. The prepared formulations were evaluated for pH, clarity, viscosity, drug content, gel strength, in vitro drug release, and stability.
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