Formulation and evaluation of lamivudine encapsulated niosomes

Authors

R.Parthibarajan
editorijipsr@gmail.com
Dept of Pharmaceutics, Cherraan’s College of Pharmacy, Telungupalayam Pirivu, Coimbatore, Tamilnadu, India
R.Kumanan Department of Pharmaceutics, Vijaya College of Pharmacy, Hayathnagar, Hyderabad.
B. Bharani Department of Pharmaceutics, Vijaya College of Pharmacy, Hayathnagar, Hyderabad.
Y. Ramulu Department of Pharmaceutics, Vijaya College of Pharmacy, Hayathnagar, Hyderabad.
S.Sudha Department of Pharmaceutical Biotechnology, St.Pauls College of Pharmacy, Turkayamjal, Hyderabad

Lamivudine, Diethyl ether, Ether injection method (ES), Hand shaking method (HS), Span 80, Cholesterol.

The aim of this present work is to formulate Lamivudine niosomes by two different methods in various ratios of

surfactant span 80. Lamivudine niosomes prepared by two methods those are hand shaking and ether injection. By

by using span 80 and cholesterol from which the best formulation was selected and characterize in terms of vesicles

size distribution, entrapment efficiency and invitro release studies. Interaction of drug and the different ingredients in

the niosomes were studied by FTIR spectra and found to be compatible. Results: The niosomes size range of prepared

formulation 0.5-5 and 0.5-2.5 by hand shaking method and ether injection method respectively. The entrapment

efficiency of lamivudine niosomes was determined by separating the entrapped drug by dialyzing method. The

entrapment efficiency of the drug was found to be more than 82% in case of niosomes prepared by hand shaking

process. The in vitro release profile of drug from niosomes was studied in 0.1 N HCL using dialyzing method and

result indicated 73.84% drug release for the formulation prepared by hand shaking method and It took an extended

period of 24 hours of drug release. In vitro release of lamivudine from niosomes was very slow when compared to

the release from pure lamivudine solution.

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