Formulation of terconazole loaded transferosomal gel for topical delivery

Authors

  • Kerryn Joseph A D Department of Pharmaceutical Chemistry, D.R. Karigowda College of Pharmacy, Hassan, Karnataka – 573201, India
  • Silva Department of Pharmaceutical Chemistry, D.R. Karigowda College of Pharmacy, Hassan, Karnataka – 573201, India
  • Sundaram T Department of Pharmaceutics, D.R. Karigowda College of Pharmacy, Hassan, Karnataka – 573201, India
  • Suresh N Department of Pharmaceutics, D.R. Karigowda College of Pharmacy, Hassan, Karnataka – 573201, India
  • Ravi KV Department of Pharmaceutics, D.R. Karigowda College of Pharmacy, Hassan, Karnataka – 573201, India
  • Preethi Fernandiz Department of Pharmacy Practice, D.R. Karigowda College of Pharmacy, Hassan, Karnataka – 573201, India

Keywords:

Terconazole, Vaginal candidiasis, Transferosomes, lipophilic.

Abstract

The present study aimed to formulate the transferosomal gel formulation of antifungal drug Terconazole for prolonged drug

release. Terconazole is an anti-fungal drug mainly used to treat vaginal yeast infections (or vaginal candidiasis). Terconazole

loaded transferosomes were prepared by modified handshaking thin-film method using a varied ratio of Soya phosphatidylcholine:

Tween 80, Soya phosphatidylcholine: Span 80, Soya lecithin: Tween 80 and Soya lecithin: Span 80. FT-IR study was carried out

to check any possible interactions between the drug and excipients. To quantify the drug concentration in the in-vitro samples, UV

spectrophotometric studies were selected. Terconazole transferosomal gel was successfully prepared which can be useful in the

treatment of fungal infection.

Dimensions

Published

2020-11-18

Issue

Vol. 10 No. 4 (2020): 2020 Volume -10 - Issue 4

Section

Articles
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