Formulation of tizanidine hydrochloride loaded solid-lipid nanoparticles using emulsification-solvent diffusion technique

Authors

  • Preethi Fernandiz Department of Pharmacy Practice, D.R.Karigowda College of Pharmacy, Hassan, Karnataka – 573201, India
  • Kerryn Joseph A D Department of Pharmacy Practice, D.R.Karigowda College of Pharmacy, Hassan, Karnataka – 573201, India
  • Suresh N Department of Pharmaceutics, D.R.Karigowda College of Pharmacy, Hassan, Karnataka – 573201, India
  • Ravi KV Department of Pharmaceutics, D.R.Karigowda College of Pharmacy, Hassan, Karnataka – 573201, India
  • Silva Department of Pharmaceutical Chemistry, D.R.Karigowda College of Pharmacy, Hassan, Karnataka – 573201, India

Keywords:

Tizanidine HCl, Muscle spasm, Solid lipid nanoparticles, Non-ionic surfactants and lipids

Abstract

The present study aimed to formulate Tizanidine HCl loaded solid lipid nanoparticles for improved drug delivery. Tizanidine

hydrochloride is a centrally acting α2-receptor agonist which regulates myotonolytic effects on skeletal muscle. Tizanidine

Hydrochloride is a muscle relaxant drug used to treat muscle spasms. Tizanidine HCl-loaded SLNs were prepared by the

emulsification-solvent diffusion method using different ratio of lipid materials (Glycerol monostearate & stearic acid) and non

ionic surfactants. Twelve batcheswere prepared using different excipients and the formulations were physiochemically stable

throughout the study period. Finally, Tizanidine HCl loaded solid lipid nanoparticles decreases the number of application of drugs.

Dimensions

Published

2020-10-23

Issue

Vol. 10 No. 4 (2020): 2020 Volume -10 - Issue 4

Section

Articles
Copyright & Licensing
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.