A review on buccal films

Abstract

The buccal region offers an attractive route of administration for systemic drug delivery. Buccal route of drug

delivery provides the direct access to the systemic circulation through the jugular vein bypassing the first pass hepatic

metabolism leading to high bioavailability.

The use of mucoadhesive polymers in buccal drug delivery has a greater application. Various mucoadhesive

devices, including tablets, films, patches, disks, strips, ointments and gels, have recently been developed. However,

buccal patch offer greater flexibility and comfort than the other devices. The novel type buccal dosage forms include

buccal adhesive tablets, patches, and films.

Buccal drug absorption occurs by passive diffusion of the nonionized species, a process governed primarily

by a concentration gradient, through the intercellular spaces of the epithelium. The passive transport of non-ionic

species across the lipid membrane of the buccal cavity is the primary transport mechanism.

The oral cavity is a complex environment for drug delivery as there are many interdependent and independent

factors which reduce the absorbable concentration at the site of absorption. i.e.. Membrane Factors and

Environmental Factors Two methods were used to prepare adhesive patches.i.e. Solvent casting and Direct milling.