Evaluation of Skeletal Muscle Relaxant Activity of Aqueous Extract of Tecoma Stans Areal Parts Sin Albino Rats

Abstract

Tecoma stans is traditionally used in various diseases because of its medicinal properties. One of its uses is

in musculoskeletal disorder. The aim of the study was to evaluate the skeletal muscle relaxant activity of the

aqueous extract of Tecoma stans areal parts (AETSAP) in albino rats in comparison with diazepam. A total of

20 Swiss albino rats aged 6-7 weeks, of either sex, weighing about 100-150 g, were taken, and after acute

toxicity studies two different doses were selected. The animals were divided into four different groups. The

first group was kept as the control (normal saline), second as the standard (diazepam) and the remaining two

groups as Test I and Test II, and given different doses of the AETSAP. Skeletal muscle relaxant activity

(motor coordination) on Rotarod and locomotor activity on photoactometer was performed. Statistical analysis

was carried out by using analysis of variance, followed by Dunnett's multiple comparison tests. The result from

the Actophotometer test and Rotarod test showed that the extract of AETSAP significantly reduced (P < 0.05)

the motor coordination of the tested animals. Our data indicates that AETSAP possesses skeletal muscle

relaxant activities.