Design and evaluation of sublingual atenolol tablets

Abstract

The research objective of this study is to formulate and evaluate sublingual Atenolol tablets.  The drug Atenolol is a selective β₁ receptor antagonist, a drug belonging to the group of beta blockers which is a class of drugs used primarily in Hypertension. The compatibilities studies were performed by using the FTIR spectroscopy. The pre-formulation studies such as Bulk Density, Tapped density hausner’s ratio were performed. Here we have used the direct compression technique to prepare optimized tablet formulation, containing Atenolol, Mannitol, sodium starch glycolate, talc provides a short DT of 60 sec with sufficient crushing strength and satisfactory friability, containing oral tablet. The Chitosan and Piperine were used in different concentration in formulation and the different Post compression parameter evaluation was performed and in vitro dissolution study was done by using the dissolution apparatus. The permeation study was carried on modified Franz diffusion cell. This study shows as all the post and pre formulation parameters were in the range as standard and the concentration of super disintegrate has significant effect on disintegration time.