Formulation development and in-vitro evaluation of controlled release of dalfampridine hydrogel beads

Abstract

The concept of formulating hydrogel beads containing Dalfampridine offers a suitable, practical approach to achieve

a prolonged therapeutic effect by continuously releasing the medication over extended period of time. In present

work, hydrogel beads of Dalfampridine were prepared successfully by ionotropic gelation method using different

polymers. Formulatd beads were evaluated for SEM, Percentage Drug content & Invitro dissolution studes.

Preformulation studies like melting point, solubility and UV analysis complied with standards. The FTIR

Spectra revealed that, there was no interaction between Dalfampridine and polymers . Surface smoothness of the

Dalfampridine beads was confirmed by SEM. As the ratio of polymer was increased, the mean particle size of

Dalfampridine floating beads was decreased. Dalfampridine floating beads with normal frequency distribution were

obtained. From invitro dissolution studies, F3 formulation containing Carbopol 940 shows prolonged and controlled

release upto 12hrs which follows zero order release with super case transport mechanism.