Psoriasis and its treatment using a topical delivery system

Abstract

Psoriasis is known as a complex, long-lasting skin illness that can have a significant impact on patients' physical and mental health.
It occurs when the immune system delivers erroneous signals that accelerate the skin's cell cycle. Numerous drugs that can be
administered orally and topically must be incorporated into the psoriasis administration regimen. The topical route circumvents the
hepatic first-pass effect, enables continuous drug delivery, has fewer adverse effects, and enhances patient compliance. Emerging
technology for the development of drug-vesicular systems can circumvent the significant limitation of low stratum corneum
permeability limit. The configuration of vesicular systems diverges from that of conventional approaches. The variation in
composition influences the shape, size, and surface features of self-assembled supra-arrangements. This refers to a variety of
transporters, including liposomes, niosomes, and transferosomes. Niosomes are formed by the self-assembly of non-ionic
amphiphiles in the presence of additional lipid surfactants in an aqueous environment. Niosomes are biodegradable, non-toxic,
amphiphilic in nature, perceptual enhancers, and an expedient in the intonation of drug discharge qualities. This review focuses on
empty topical systems intended for the treatment of psoriasis and the efficacy of niosomal topical delivery for psoriasis treatment.