Preparation, characterization, and in-vitro evaluation of decitabine microspheres

Abstract

The main aim of any drug therapy is to achieve a desire concentration of the drug in blood or tissue, which is therapeutically effective
and non-toxic for an extended period of time. This can be achieved by proper design of controlled-release dosage regimen. Various
approaches have been developed for controlled release; Microspheres are the potential candidate for controlled release of drug.
Decitabine microsphere were prepared with a coat consisting of alginate and polymer such as HPMC and Sodium alginate by Ionic
cross-linking technique using CaCl2. The microspheres were evaluated with respect to the yield, particle size, Drug entrapment
efficiency, in vitro drug release and stability. Microspheres were characterized by FTIR studies. It was found that the particle size
and Drug entrapment efficiency of microspheres increases with increasing drug-to-polymer ratio.