Formulation and invitro evaluation of extended release tablet of ibrutinib

Abstract

The aim of the present study was to develop Ibrutinib extended release tablets to maintain constant therapeutic levels of
the drug for over 12 hrs. Guar gum, Karaya gum and Acacia were used as polymers. All the formulations were passed
various physicochemical evaluation parameters such as Bulk Density, Tapped Density, Carr’s Index, Hausners Ratio,
Angle of Repose, Weight Variation, Hardness, Thickness, Friability and Drug Content. From the dissolution studies it was
evident that the formulation I6 showed better and desired drug release pattern i.e., 99.14 % in 12 hours. It contains the
Karaya gum as polymer. It followed Kars mayer peppas release kinetics mechanism. In conclusion the results suggest that
the developed matrix tablets of Ibrutinib could perform therapeutically better than conventional dosage form, leading to
improved efficacy and better patient compliance