Synthesis and Pharmacological Screening of New Benzothiazole Derivatives

Abstract

A new series of five compounds of benzothiazole were synthesized by ring closure reactions of different 4,6-disubstitued-benzo(d)thiazo  with aniline and potassium thiocyanate separately. Further, the 4,6-disubstitued-benzo(d)thiazo were treated with aromatic amines , hydarazine hydrate and Thiosemicarbazide. The structures of the synthesized compounds were consistent with IR, spectroscopy. The synthesized compounds were screened by disc diffusion method for their antibacterial and antifungal activity. Among the compounds synthesized SV-3 and SV-5 shown significant antimicrobial activity against both bacterial and fungal strains.The synthesized compounds (SV-3 and SV-5) were tested for their antiinflammatory activity.