Comparative Standardisation of Four Marketed Formulations of Karppooraadi Churna

Abstract

Abstract: Standardisation of herbal formulation is essential in order to assess the quality of drugs for therapeutic value as it is a plant-derived material containing raw ingredients. According to an estimate of world health organization (W.H.O) most of the developing countries rely on traditional medicines. Standardisation of herbal formulations is essential to ensure their quality, safety, and therapeutic efficacy, as variability in plant-based raw materials can influence formulation consistency. The present study aimed to comparatively standardise four marketed formulations of Karpooradi Churna, an Ayurvedic polyherbal preparation commonly used in the management of respiratory disorders. The selected formulations were evaluated for organoleptic characteristics, physicochemical parameters (total ash, acid-insoluble ash, extractive values, and loss on drying), physical properties (bulk density, tapped density, angle of repose, Carr’s index, and Hausner’s ratio), pH, and qualitative phytochemical constituents following World Health Organization guidelines. Total ash values ranged from 33.96–37.23% w/w, while water-soluble extractive values varied between 4.8–10.4% w/w. Loss on drying was found to be within 1–1.2% w/w, and pH values indicated a mildly acidic nature (5.82–6.06). Phytochemical screening revealed the presence of alkaloids, carbohydrates, terpenoids, and tannins in all formulations.

The findings indicate that all four marketed formulations complied with acceptable quality control parameters. The generated data may serve as reference standards for routine quality assessment and contribute to the standardisation of Karpooradi Churna formulations.