Formulation And Evaluation Of Rapid Release Oral Film Of Sucralfate

Abstract

The review was designed “Formulation and Evaluation of Fast Dissolving Films of Sucralfate by Solvent Casting Method”. In this research, rapidly dissolving films of sucralfate were developed using low viscosity grades of HPMC as film forming polymers. HPMC is a water soluble synthetic polymer which was used as film former form many years. The films of sucralfate were prepared by solvent casting method using suitable as solvents. The prepared films were evaluated for drug content, weight variation, thickness and in vitro in vivo disintegration time. Sucralfate is moderately bitter drug; taste masking was achieved by use of sweeteners, flavours. Type of flavor significantly affected the taste masking property. The in vitro disintegration time of the optimized formulation was found to be below in the marketed preparation respectively. The prepared films exhibited good integrity and thickness. In vitro dissolution studies were performed as per the FDA dissolution guidelines for about 10 minutes, the optimum formulation released complete drug within 4-6 minutes.  FTIR studies were showed no drug polymer interaction.