A Method Development for Rabeprazole Sodium And Itopride Hydrochloride Simultaneously By Hplc

Authors

  • D. Jeevan Mani Babu Principal,Department of Pharmacology, St.Xavier Institute of Pharmacy, Deenapur, Phirangipuram, Andhra Pradesh, Pin code:522529.
  • Pothula viswanath Department of Pharmaceutical Analysis, St.Xavier Institute of Pharmacy, Deenapur, Phirangipuram, Andhra Pradesh, Pin code:522529.
  • J. Madhavi Latha Associate Professor, Department of Pharmaceutical Analysis, St.Xavier Institute of Pharmacy, Deenapur, Phirangipuram, Andhra Pradesh, Pin code:522529.
  • R. Marcy Rani Department of Pharmaceutical Analysis, St.Xavier Institute of Pharmacy, Deenapur, Phirangipuram, Andhra Pradesh, Pin code:522529.

Keywords:

Itopride, Rabeprazole, RP-HPLC

Abstract

The retention time of RP, PP, and IP were 5.35, 7.92, and 11.16 minutes, respectively. Validation of the proposed method was carried out according to International Conference on Harmonisation (ICH) guidelines.. The calculated limit of detection (LOD) values were 1, 0.3, and 1 μg/mL and limit of quantitation (LOQ) values were 2.5, 1, and 3 μg/mL for RP, PP, and IP correspondingly. Thus, the current study showed that the developed reverse-phase liquid chromatography method is sensitive and selective for the estimation of RP, PP, and IP in combined dosage form.

Dimensions

Published

2025-03-14

Issue

Vol. 15 No. 1 (2025): 2025 Volume -15 - Issue 1

Section

Articles
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