Formulation, Evaluation, Pack design & Commercialization of Chlorine Dioxide Gas for Disinfection & Chlorine Dioxide Tablet for Water Treatment

Authors

  • Packiaraj Jeyachandran Manohari Chief Scientific Officer, Eywa Hibrow Pharma Pvt Ltd and Nutrimed Lifesciences Pvt Ltd, Survey No 258, Thiruvandavar Village, Sirupinayur Panchayat, Uthiramerur Taluk, Kanchipuram District, Chennai, Tamil Nadu – 603308, India.
  • Venkateswaran Chidambaram Seshadri Chief Scientific Officer, Eywa Hibrow Pharma Pvt Ltd and Nutrimed Lifesciences Pvt Ltd, Survey No 258, Thiruvandavar Village, Sirupinayur Panchayat, Uthiramerur Taluk, Kanchipuram District, Chennai, Tamil Nadu – 603308, India.
  • Yeshwanth Kamalakannan School of Pharmacy, Sathyabama Institute of Science and Technology, Rajiv Gandhi Salai, Seemanjeri, Chennai, Tamil Nadu – 600119, India
  • Arunsundar Mohanasundaram School of Pharmacy, Sathyabama Institute of Science and Technology, Rajiv Gandhi Salai, Seemanjeri, Chennai, Tamil Nadu – 600119, India
  • Janakiraman Kunchithapatham Professor and Head of the department, Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu – 608002.
  • Guhan Himadeep Chowdary Eswara Rao Chief Scientific Officer, Eywa Hibrow Pharma Pvt Ltd and Nutrimed Lifesciences Pvt Ltd, Survey No 258, Thiruvandavar Village, Sirupinayur Panchayat, Uthiramerur Taluk, Kanchipuram District, Chennai, Tamil Nadu – 603308, India.

Keywords:

Disinfection, Sterilization, Fumigation, Decontamination

Abstract

In this research, we have explored and realized safe and effective utility of Chlorine Dioxide gas as a means for disinfection and Chlorine Dioxide Tablet for Water treatment. For generation of Chlorine Dioxide gas, a suitable reactant mixture was formulated. The reactant mixture composition and the extent of gaseous Chlorine Dioxide generation were suitably optimized. Sodium Chlorite and Anhydrous Citric Acid as reactant mixture in the ratio of 9.02:0.98 / 20.8 g: 2.2 g was finalized which produced about 2500 ppm of Chlorine Dioxide gas for effective disinfection of 250 square feet of area. For testing the disinfectant efficiency, a simple but efficient chemical and microbial evaluation method were designed and utilized. Apart from formulation and evaluation, a suitable pack for the reactant mixture was designed and fabricated so that the contents remain intact and stable during storage and active enough to produce Chlorine Dioxide gas when put to use. The formulated product was found to be stable in the intended packing configuration. The product was successfully commercialized at an affordable price under the brand name CAIR®. Also in this research for Water treatment purpose, Acidulated Chlorine Dioxide Effervescent tablets were formulated by direct blending and compression process. Physico-chemical evaluation was done for the formulated tablets. One (1) tablet produced 0.8 mg / L of Chlorine Dioxide gas sufficient enough to treat about 1 Litre of Water free of pathogens, spores, parasites & cysts. A suitable pack was designed and stability tested to ensure the product remains stable while handling and storage. The product was successfully commercialized at an affordable price under the brand name JAL4AL®.

Dimensions

Published

2025-02-18