Formulation and evaluation of muco adhesive buccal tablets of chlorhexidine

Abstract

Chlorhexidine is an antiseptic and disinfectant. It helps reduce the number of germs (bacteria) in your mouth or on your skin. It can help with: mouth infections, mouth ulcers and gum disease. Aim of the present work is to formulate and evaluate of mucoadhesive tablets of Chlorhexidine by using different polymers like HPMC K15M, Tragacanth and Carbopol. The tablets were formulated by direct compression method and were evaluated for various pre-compression and post compression parameters such as hardness, friability, thickness, weight uniformity, drug content, drug release, swelling index and In vitro drug release. FTIR showed no interaction between drug and polymers. The optimized formula consisted of Chlorhexidine and HPMC K15M with 20mg and showed maximum drug release for 8hours is 99.58 % for C3 formulation. The C3 formulation is consider as optimized formulation of mucoadhesive buccal tablets and Kinetics are done.