A review on floating drug delivery system

Abstract

This review explores the advancements in Floating Drug Delivery Systems (FDDS), emphasizing their classification, mechanisms, and methodologies for sustained drug release. FDDS enhance the bioavailability of drugs with short half-lives by prolonging their retention in the gastrointestinal tract. Key technologies include effervescent and non-effervescent systems, raft-forming systems, and floating microspheres, each offering distinct advantages in gastric retention and drug release kinetics. The paper also discusses the preparation methods, such as direct compression, dry granulation, and wet granulation, and evaluates critical parameters like floating lag time, bulk density, and dissolution profiles. FDDS present a promising approach for targeted drug delivery in the upper gastrointestinal tract, addressing challenges in drug absorption and therapeutic efficacy.