Formulation and evaluation of eplerenone immediate release 25mg tablets

Abstract

The present study aimed to improve the Solubility and Dissolution ratio of Eplerenone by preparation of Eplerenone nanosuspension by via nano-precipitation method. There is poor solubilities and slow dissolutions comparison are principal concerns for the edge of approaching drugs and presented biologically active combinations. Eplerenone is highly selective aldosterone blocker. It is treated for therapy of hypertension and heart failure, but question related with its poor solubility in biological solutions. Eplerenone is BCS Class-II having high permeability low and solubility. All the Eplerenone nanosuspension preparations were characterization for its Particle size and its distribution, Scanning Electron Microscopy, Zeta potential analysis, Drug excipient interactions investigated by using FT-IR examinations, Entrapment Efficiency (EE) and in vitro release kinetics. The adjusted formulation (Trail 6) showed an average particle size and zeta potential is 169.5.05 nm and -58 mV respectively. The dissolution profiling rate for the optimized nanosuspension was better relative to Eplerenone mainly due to the design of nanosized particles. Stability search discovered that nanosuspension was more stable at ambient room and cold condition with no significant change in particle size distribution. These effects indicate that the Eplerenone loaded Nanosuspension significantly increased in-vitro dissolution rate and thus probably enhance immediate start of therapeutic medication effect.