Formulation And Evaluation Of Irbesartan Orally Disintegrating Films

Abstract

Orally disintegrating films may accelerate the medication's onset of action, reduce dosage, and improve its efficacy and safety profile. It dissolves faster, is more stable, and lasts longer than other traditional dose forms. In order to create fast-dissolving films that dissolve in saliva rapidly and without the need for water, Irbesartan (IRB) was chosen for the sublingual route. The purpose of IRB oral disintegrating films was to increase patient compliance and bioavailability. The formulas were created with the intention of helping elderly, bedridden, and mentally ill people. IRB is used to measure the effect on the dissolution profile. The orally disintegrating films (ODF) were prepared using the solvent casting technique with water soluble polymers such as HPMC E3, HPMC E6, and Xanthan gum of various concentrations and PEG 400 as a plasticizer and an active ingredient. The medication dissipated rapidly, according to the results. This study suggests that an oral disintegrating film may be used to give IRB orally. ODF formulations dissolve smoothly and easily, releasing the entire medication within 20 to 30 minutes. Following disintegration, no remnant or particle matter was remaining. It was determined that the solvent casting method was effective in producing the quickly disintegrating IRB films. When there is no access to water, oral disintegrating films (ODF) have been effectively used with bedridden and psychotic patients as well as travelers. Prepared films demonstrated a higher rate of dissolution and a quicker start to action, which led to improved patient compliance, successful therapy, and increased use in the near future.