Design and invitro characterization of alfuzosin HCL tablets for sublingual drug delivery system

Abstract

Alfuzosin HCl (ALF) that is commonly used to treat benign prostatic hyperplasia (BPH), on the market. On the other hand, ALF-containing orally disintegrating tablets (ODTs) are not yet available for purchase. To make the selected medicinal molecule more soluble and to speed up its dissolving rate, this study developed sublingual tablets of ALF employing super disintegrating agents such as sodium starch glycollate, locust bean gum, and cross caramellose sodium. All of the formulations were prepared using the direct compression method with a 6-millimeter punch on an 8-station rotary tablet punching machine. All things considered, the mixtures displayed good flow properties including bulk density, tapped density, and angle of repose. All of the quality control evaluation parameters were met by the produced tablets, and they demonstrated good post compression properties according to the I.P limits. Optimal performance was achieved by the AF1 formulation, which exhibited the highest percentage of drug release (99.78%) in under 6 minutes. A super disintegrates containing ten milligrams of SSG is included in the AF1 formulation. According to the results of the permeability tests, ALF is an easily absorbed substance. Based on these results, the ODT method for ALF seems to be a good way to get patients to comply with treatment and get things rolling quickly.