Development and Evaluation of Baicalein & Berberine Containing Dental Gel for Human Periodontal Disorder Management

Abstract

Periodontal diseases are primarily caused by infections and inflammation affecting the gums and the bone structure that support the teeth. These conditions are highly prevalent across the globe, impacting individuals of all ages, from children to adults. In the context of oral hygiene, dental gels play a vital role by delivering therapeutic agents directly to the oral cavity, thereby helping to manage and prevent such diseases. This study focused on the development and optimization of a dental gel using Carbopol 934 as the gelling agent. The aim was to formulate a dental gel containing the active compounds baicalein and berberine, known for their antimicrobial properties. Various concentrations of carbomer were utilized to develop different gel formulations, which were then subjected to a comprehensive evaluation of their physicochemical properties. These properties included pH, color, clarity, viscosity, consistency, homogeneity, and spreadability. Through thorough analysis, the optimal gel formulation was identified based on its superior physicochemical characteristics. This optimized formulation was subsequently tested for antimicrobial activity using the agar disc diffusion method. The results from this testing were promising, indicating that the dental gel exhibited significant antimicrobial activity against the bacterial strains used in the study. Overall, the study successfully demonstrated that the dental gel, formulated with baicalein and berberine and optimized with Carbopol 934, has potential as an effective antimicrobial agent in the treatment and prevention of periodontal diseases.