Preparation, Characterization and Optimization of Famciclovir loaded Solid lipid Nanoparticle for enhancing Antiviral Therapy

Abstract

The current study was undertaken to develop solid lipid nanoparticles (SLN) of a hydrophilic drug Famciclovir and improve the entrapment efficiency of the drug in SLN. The SLN were prepared with Compritol 888 ATO as lipid using solvent-evaporation technique by Box Behnken design. Three operating variables lipid  concentration, Surfactant and Sonication time were found to have significant effect on the particle size and entrapment efficiency (EE) of the SLN. The maximum EE was found to be 89% with particle size of 299.4nm which was significantly higher than that reported earlier. The optimized batch was also analyzed for its morphological, physiochemical and ex vivo intestinal permeation properties. This work indicates that Famciclovir loaded in SLN could be better option for enhancing the permeability of Famciclovir in intestine as compared to existing marketed  formulations.