Design and Evaluation Of Esomeprazole Medical Trans-dermal Drug Delivery Patches

Abstract

The goal of the present research work is to formulate, development and characterization of transdermal systems used to treat gastro-esophageal, peptic-ulcer disease, and Zollinger–Ellison syndrome. Formulations were prepared by employing combination of HPMCK15M, PVPK30, and EC in various ratios. From the research, various conclusions were drawn. The patches showed good thickness, tensile strength and content uniformity of drug. The used polymers (HPMCK15M, PVPK30, and EC in various ratios) employed to design transdermal patches in different proportion. Invitro release from transdermal patches showed extended release of drug for 24 hours. The Esomeprazole penetration from formulated transdermal patches was found to follow diffusion mechanism and obeys zero order release. So we can conclude that transdermal delivery system would be used as drug carrier for Esomeprazole.